Search results for "Apurinic Acid"

showing 3 items of 3 documents

Apurinic acid, a modified DNA with anticancer activity

1971

Apurinsaure, ein purinfreies hochmolekulares Desoxyribonukleinsaure-Derivat, hemmt das Wachstum des menschlichen Kolontumors GW-77 und das amelanotsiche Melanom des Hamsters.

PharmacologyModified dnaNucleotidesChemistryAntineoplastic AgentsNeoplasms ExperimentalCell BiologyCellular and Molecular NeuroscienceCheekBiochemistryCricetinaeColonic NeoplasmsAnimalsHumansMolecular MedicineMelanomaMolecular BiologyApurinic AcidNeoplasm TransplantationExperientia

researchProduct

�ber die Wirkung von Apurins�ure und Apyrimidins�ure auf die enzymatische Desoxyribonukleins�ure-(DNA-) Synthese in vitro

1970

The effect of chemically modified deoxyribonucleic acid (DNA) on enzymatic DNA-synthesis in vitro has been investigated with analogues of DNA prepared without either purine bases (apurinic acid, APA) or pyrimidine bases (apyrimidinic acid, APyA). DNA-synthesis in vitro was studied with the deoxynucleotide polymerizing enzymes purified from calf thymus (replicative and terminal deoxynucleotidyltransferase respectively).

Pharmacologychemistry.chemical_classificationPurinePyrimidinebiologyDNA polymeraseGeneral MedicineMolecular biologyIn vitrochemistry.chemical_compoundEnzymechemistryBiochemistryApyrimidinic acidbiology.proteinApurinic AcidDNANaunyn-Schmiedebergs Archiv f�r Pharmakologie

researchProduct

Hemmung von DNA-Synthese und Zellvermehrung durch Apurins�ure und Apyrimidins�ure

1968

Apurinic acid (APA) and apyrimidinic acid (APyA) prepared from deoxyribonucleic acid (DNA) by removing either purine or pyrimidine bases have been reported to inhibit enzymatic DNA-synthesis in vitro (Heicke, 1970). The present paper deals with in vivo effects of APA and APyA on mammalian cells in tissue culture.

Pharmacologychemistry.chemical_classificationPurinePyrimidineeducationGeneral MedicineBiologyMolecular biologyIn vitroTissue culturechemistry.chemical_compoundEnzymeBiochemistrychemistryIn vivomental disordersApurinic Acidpsychological phenomena and processesDNANaunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie

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